Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants
Identifieur interne : 003A41 ( Main/Exploration ); précédent : 003A40; suivant : 003A42Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants
Auteurs : Renate Lüllmann-Rauch [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1975-12-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal inclusions, Academic press, Acid hematein, Antidepressant, Approx, Araldite section, Autophagic activity, Cell types, Chlorphentermine, Considerable numbers, Cytological alterations, Cytoplasmic inclusions, Dense bodies, Dense inclusions, Distal tubules, Duct, Duct cells, Duct system, Electron microscope, Electron microscopy, Epithelial cells, Generalized lipidosis, Generalized phospholipidosis, Glomerular podocytes, Hematein, Higher magnification, Histochemical demonstration, Histochemical properties, Holland publishing, Inclusion, Inner medulla, Interstitial cells, Iprindole, Lamellar, Lamellar bodies, Lamellar inclusions, Lamellated, Light cells, Lipidosis, Lysosomelike bodies, Medulla, Multilamellated cytoplasmic inclusions, Other tissues, Outer medulla, Outer region, Outer stripe, Phospholipid, Proximal, Renal, Renal cortex, Renal tissues, Same animal, Staining material, Straight portions, Thin limb, Tricyclic, Tricyclic antidepressants, Tubule, Ultrastructural appearance, Untreated control, Uriniferous tubules, Virchows arch.
Abstract
Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.
Url:
DOI: 10.1007/BF02889233
Affiliations:
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B Cell Path.</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1975-12-01">1975-12-01</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="51">51</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0340-6075</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-depressants, Tricyclic</term><term>Chlorphentermine</term><term>Kidney</term><term>Lipidosis, Drug-Induced</term><term>Rat</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormal inclusions</term><term>Academic press</term><term>Acid hematein</term><term>Antidepressant</term><term>Approx</term><term>Araldite section</term><term>Autophagic activity</term><term>Cell types</term><term>Chlorphentermine</term><term>Considerable numbers</term><term>Cytological alterations</term><term>Cytoplasmic inclusions</term><term>Dense bodies</term><term>Dense inclusions</term><term>Distal tubules</term><term>Duct</term><term>Duct cells</term><term>Duct system</term><term>Electron microscope</term><term>Electron microscopy</term><term>Epithelial cells</term><term>Generalized lipidosis</term><term>Generalized phospholipidosis</term><term>Glomerular podocytes</term><term>Hematein</term><term>Higher magnification</term><term>Histochemical demonstration</term><term>Histochemical properties</term><term>Holland publishing</term><term>Inclusion</term><term>Inner medulla</term><term>Interstitial cells</term><term>Iprindole</term><term>Lamellar</term><term>Lamellar bodies</term><term>Lamellar inclusions</term><term>Lamellated</term><term>Light cells</term><term>Lipidosis</term><term>Lysosomelike bodies</term><term>Medulla</term><term>Multilamellated cytoplasmic inclusions</term><term>Other tissues</term><term>Outer medulla</term><term>Outer region</term><term>Outer stripe</term><term>Phospholipid</term><term>Proximal</term><term>Renal</term><term>Renal cortex</term><term>Renal tissues</term><term>Same animal</term><term>Staining material</term><term>Straight portions</term><term>Thin limb</term><term>Tricyclic</term><term>Tricyclic antidepressants</term><term>Tubule</term><term>Ultrastructural appearance</term><term>Untreated control</term><term>Uriniferous tubules</term><term>Virchows arch</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Histological, histochemical and ultrastructural examinations were performed on renal tissues of rats after prolonged oral administration of the anorectic drug chlorphentermine or of the tricyclic antidepressants iprindole, imipramine and clomipramine. All drugs caused the formation of multilamellated cytoplasmic inclusions throughout the nephron and the collecting duct system, and in interstitial cells. The cytological alterations were most prominent in the glomerular podocytes, in the proximal convoluted tubules, and in the collecting duct system. In view of the histochemical properties (staining with Baker’s acid hematein) and the ultrastructural appearance of the cytoplasmic inclusions the cellular alterations are interpreted as a renal manifestation of a generalized lipidosis induced by drugs of amphiphilic character.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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